Friday, August 1, 2008

Gene of Schizophrenia?

A recent advance in studying the genetics of schizophrenia is reported in this Nature article.

There are reasons why scientists keep looking vigorously for the genetic basis of psychiatric disorders despite decades of unsuccessful efforts. With such persistence it is likely that some kind of genetic association will finally be found, or at least claimed to be found. Given the computational complexity and sample sizes of the modern genetic studies, many years could pass before the results of any given study could be verified or disproved.

What worries me is that psychiatry has a tradition of trumpeting the first promising results of a new study and rushing them into practice before the results are verified. And the nature of the specialty is such that once something new is implemented, it confuses the picture so much that it becomes impossible to say if the new method was even helpful.

In practice, as soon as some believable hint is received that psychiatric disorders are genetic in nature, and some genetic testing procedures become available, it will make the case for preventive use of psychotropic drugs on people who are "at risk". This makes no scientific sense (I'll explain this point next time, otherwise I'll be late for my train), but this most definitely will be done.

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