Prozac As Good As Placebo

In a PLoS Medicine article, a British professor Irving Kirsch and his colleagues have reported that the antidepressant drugs like Prozac are not more efficient then placebo in the treatment of depression.

The authors have gained access to, and analyzed the data from the unpublished trials of these medications.

Even before that, according to the most optimistic data from the published studies, the drug and placebo response rates were around 50% and 40% respectively. Now when the unpublished studies are taken into account, it turns out (perhaps not surprisingly) that the drug-placebo difference is almost non-existent.

A Guardian article comments on this more extensively, and describes some drug producers's reaction to these findings.